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The exception was heart cytosol where the label was associated with higher molecular weight proteins. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. Introduction of intrasubunit chemical cross-links into HA reversibly inhibited both Y8-10C2 binding to trimers at elevated temperatures and viral fusion activity, indicating that exposure of the epitope requires the normal conformational flexibility of the molecule. Many optical imaging systems have been designed to achieve spatial resolution exceeding the limit proposed by Abbe theory, namely lambda/2NA. Maintaining movement ability in old age: challenges for gerontechnology.

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It is suggested that the 24 kDa D1-polypeptide breakdown product is the same as that first observed in vivo by Greenberg et al. The Hazard Ratios, calculated for each prognostic factor, showed no difference in all outcomes between the 2 treatment sequences. Antibodies against arylcyclohexylamines and their similarities in binding specificity with the phencyclidine receptor. Neuronal density varies less across cortical areas in prosimian galagos than in the Old World monkeys. We detected that salt-induced expressions of a transcriptional repressor gene, AtERF4, and some Ser/Thr protein phosphatase2C genes, ABI1, ABI2 and AtPP2CA, were suppressed in BrERF4-overexpressing Arabidopsis plants.

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Effect of varying channel capacity on stimulus detection and discrimination. The results of this study suggest that whole-body vibration exercise using a Galileo machine appears to be useful in reducing chronic back pain, probably by relaxing the back muscles in post-menopausal osteoporotic women treated with alendronate. LVH related to the time-course of renal function in Japanese hypertensive patients.

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In the absence of somatic manifestations, regular clinical surveillance was decided on. The amino acid sequences of eleven RIPs sequenced to date have been compared in the expectation that this would be useful in the location of functionally and/or structurally important sites of these molecules. The aim of this study was to examine the inflammation induced by saturated acyl lysophosphatidylcholine (LPC) in vivo and to investigate whether it could be attenuated by the action of polyunsaturated acyl lysophosphatidylcholines (LPCs), which are known as anti-inflammatory lipid mediators. The present study was undertaken to determine whether cross-tolerance develops between NT and ethanol and whether chronic NT infusion produces NT receptor downregulation.

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An immuno-histological study of metastatic adenocarcinoma has revealed the following results. L-Histidine, intended as a pseudobiospecific ligand, was immobilized on poly(ethylenevinyl alcohol) hollow fibre membranes after their activation with epichlorohydrin or butanediol diglycidyl ether. Condensation of the oocyte chromatin into a compact karyosome is also defective in Src64, Tec29, and kelch mutants and in mutants for spire and chickadee (profilin), genes that regulate actin polymerization.

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It is suggested that the inhibition of myogenic vascular reactivity is a factor contributing to the edema formation of calcium antagonists. Comparative survival analysis using Kaplan-Meier estimates after censoring data at 28, 42, 84, 182, and 365 days and Cox proportional hazard method was used to estimate hazard rates after controlling for difference in baseline neutropenia.

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These results suggested the limitation of evaluation using test food, so dentists should observe eating behaviour of in-patients. Development and application of adenoviral vectors for gene therapy of cancer.

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Role of NO on pressure-natriuresis in Wistar-Kyoto and spontaneously hypertensive rats. The results show that females, participants in individual sports, and members of non-vocationally active households were less affected by the interventions. The number of independent pair interaction parameters is chosen to be small enough to be physically meaningful yet large enough to give reasonably accurate results in discriminating decoys from native structures. The increased diagnoses of autism and developmental disorders in recent decades, together with the childhood vaccination program, has led to the hypothesis that vaccination in general, and the measles, mumps, and rubella virus live vaccine, and vaccines that contain mercury, in particular, cause autism.

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In this way, we were able to differentiate the two toxins since they had a different profile of gene expression. The effect of the intervention on the consumption of fluoroquinolones and bacterial resistance was assessed using segmented regression analyses. This study had two aims, to investigate the inter-relationships of age, symptoms, and various zonal measurements in the prostate and to assess the impact of heritable influences on symptom score. Clinical observation on familial pheochromocytoma--case report and literature review

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Seventeen of the 18 patients recovered without any complications, although epidural abscesses in the anterior skull base had been present in four patients at the time of the operation. Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Sixty-nine consecutive patients who underwent PLV were monitored with pressure-volume relationship analyses, Doppler echocardiography, and histopathologic studies of excised myocardium. In conclusion, our results indicate for the first time the presence of c-mos products in an elasmobranch species and, moreover, their presence in somatic testicular cells rather than germ cells. Humoral autoimmune reactions directed against autoantigens of the H-2 histocompatibility system in mice with developing Rauscher leukemia

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Larvicidal and persistent efficacy of an imidacloprid and moxidectin topical formulation against endoparasites in cats and dogs. Supportive care remains a crucial aspect in the management of MM.

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As part of the Consumer-Operated Multi-Site study funded by the Substance Abuse and Mental Health Services Administration, consumers with a psychiatric disability were administered the Empowerment Scale along with several other scales to measure clinical status and psychosocial factors. We have studied a large number of patients with epilepsy who are on either monotherapeutic or polytherapeutic regimens of most of the common anticonvulsants. Magnetically induced current densities in Al4 (2-) and Al4 (4-) species studied at the coupled-cluster level.

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The CRS parameters were determined in humans at the age of 5-65. Action plans developed in this manner should be more useful for the early detection of deteriorating asthma. These results suggest that this heparin bonding method with PU appears to have good antithrombogenicity with possible long durability. In addition, MHC class I antigen expression appeared to increase in heart biopsy samples early during the post-transplant period, followed sequentially by an increase in the level of MHC class II antigen expression.

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In kinase assay, we show that CCII domain could readily be phosphorylated by AIK and PKA. Certain structural changes contribute to differences in pharmacokinetic properties such as a prolonged half-life (15 min), which allows it to be administered as two 10-MU bolus injections. Rewarding properties of d-amphetamine, measured by conditioned place preference, were similar in both genotypes. In both preparations EAD appeared after 5-15 min exposure to CsCl and the take-off potentials (TOP) were in the same range (-30 to -60 mV).

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Comparisons of weighted frequency distributions between sites demonstrated that differences in egg production in the third generation were due to increases in the proportion of reproductive zooids within a colony. Cytophotometric analysis of T-2 toxin induced alterations in chromatin condensation and neuronal nuclear volume of rat supraoptic-magnocellular neurons.

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Cells were synchronized by mitotic selection and thymidine-hydroxyurea methods. Purification of hemoglobin contaminated albumin solutions by means of zinc salts

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After this time, their expression became uniform even though the histological pattern of barrel walls and hollows was maintained. Rising to the challenge: tools for enrolling eligible children in health coverage. As differentiated from standard doses, phenazepam in this concentration did not affect other frequency bands. Prompt diagnostic accuracy will help avoid unnecessary costs and risks in the workup of such patients. Constitutively activating mutations have recently been identified in the thyrotropin receptor (TSHR) of hyperfunctioning thyroid adenomas and familial hyperthyroidism.

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A decrease of PGE2 synthesis could be due to competitive and inhibitory effects of fatty acids other than arachidonate, observed in the kidney phospholipid composition in our dietary conditions. Ten consecutive cases of balloon kyphoplasty were performed under general anaesthesia in the prone position, on a single vertebral level using a two-step technique under combined fluoroscopic and CT guidance.

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PCR amplification of macrolide resistant erm (encoding methylase) and mef (encoding macrolide efflux pump protein) genes was carried out. Thirty-seven new subjects were diagnosed as having ADHD in 2000, and 36 of them were treated with methylphenidate. Probabilistic diagnosis using a reformulation of the INTERNIST-1/QMR knowledge base.

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IOTF-recommended BMI cutoff values had low sensitivity and may underestimate the local prevalence of childhood obesity. Gross motor function improvements were observed at the end of the intervention period.

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we propose that while a large degree of atrial septal movement significantly increases propensity to cerebral embolism in patients with PFO, its absence does not negate this risk. QTLs with possible pleiotropic effects on both spawning date and body size were localized to two linkage groups. Strategies for promoting adherence and safety were also discussed. Results revealed higher baseline blood pressure, increased CVR characterized by a vascular hemodynamic profile, and more rapid recovery (especially during encoding) for older than for younger participants.

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The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids. This study examines the integrative response of several duodenal functions to nitric oxide synthase inhibition. Remarks on the Treatment of Piles and Allied Affections: Read before the Medical Society of London, March 7th, 1892.

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Grafted systems obey the Stokes-Einstein relationship over the temperature range simulated, but ungrafted systems display deviations from it. In addition to fibrosis and inflammation, which used to be considered the main pathology of frozen shoulders, chondrogenesis is likely to have a critical role in pathogenesis of idiopathic frozen shoulders. Interestingly, phorbol myristate acetate together with IKKalpha gene transfection strongly inhibited the expression of involucrin in SCC cells and induced the phosphorylation of serine residue in IKKalpha, suggesting that protein kinase C is involved in the effect of IKKalpha on the differentiation of SCC cells. Use of the proposed scheme will render objectiveness and reliability to conclusions of forensic medical experts.

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The major outer membrane protein (MOMP) is the prime candidate for the development of a chlamydial vaccine. Staining for K8 and K18 was seen in the apical region of the pocket lining and in the finger-like extensions of epithelium into the connective tissue. This research aims to assess the incidence and trend of CS in a population-based birth register in order to identify patient groups with an increasing risk for CS.

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Immunoglobulin isotype-specific antibody responses to pneumococcal polysaccharide vaccine in patients with recurrent bacterial respiratory tract infections. Thus, At13HPL may not only be used for the production of C6-derived volatiles, but depending on the substrate may be further used for the production of Cg-derived volatiles as well. It is concluded from this result that the influence of muscle fatigue on skiing performance is related to skill level.(1). On some Cases of Haemorrhage into the Skin and Suprarenal Capsules. It is proposed that the chromatin in heterochromatic chromosomal regions is generally similar in its molecular composition to that in silenced chromosomal regions.

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Isolation of Bacillus sphaericus biotin synthesis control mutants: evidence for transcriptional regulation of bio genes. Analysis of the activity and phosphorylation of the lck protein in lymphoid cells. Asian Indian women have a higher rate of coronary artery disease (CAD) than do other ethnic groups, despite similar conventional risk factors and lipid profiles.

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Differences in the protein pattern between the three groups were observed. We describe two different computational approaches, realized as the fast, flexible docking program FlexX and as the de novo design program LUDI. A new evaluation 1 year after the DiBiCol allowed the assessment of clinical diagnosis in 10 patients confirmed in 9 of 10 patients by DiBiCol.

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The study included 25 patients, aged 58-76, with mild to moderate PD and 25 healthy controls matched for age, sex and education, with an average mileage of over 3000 km/year. A photoactivated diazopyruvoyl cross-linking agent for bonding tissue containing type-I collagen. saprophyticus, and provided more precise information on the femA start codon for all five species. A 27-year-old male presented with low back pain and radiculopathy and radiographic evidence of degenerative disc disease and foraminal stenosis. Pancreatic secretion of digestive enzymes, amylase, trypsinogen and chymotrypsinogen, was studied in response to the wing vein injection of digestive end products, various single amino acids and glucose, with or without cholecystokinin (CCK) in chicks.

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Effects of adrenomedullin on ocular hemodynamic parameters in the choroid and the ophthalmic artery. The spiculogenic cells were separated from other cell types of the embryo, frozen, and freeze-dried on the TEM grids. Phonological behavior in toddlers with slow expressive language development. Consistent with these findings, histologic analysis for TRAP-expressing cells reveals extensive osteoclastogenesis in animals harboring HPSE tumors. Furthermore, Gnot1 activation by polarizing signals occurs temporally downstream of Hoxd gene activation, but well before the first appearance of condensations that will give rise to the carpus of the wrist.

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The diagnostic value of nucleolar margination, defined as the percentage of nucleoli touching the nuclear membrane, was investigated in 359 cytological preparations of benign and malignant lesions of the thyroid, breast, prostate and central nervous system. It explains how radiographic images of the cervical spine can differentiate tumors, inflammation, recent or prior trauma, and the range of discal, arthritic, neural, and vascular cervical pathologies and, just as importantly, when they cannot. Urinary organic acid analysis showed the presence of 4-hydroxybutyric acid and other metabolites consistent with the diagnosis 4-hydroxybutyric aciduria. Periodate oxidation abolished reactivity of the antibodies to GD3 but not that to O-AcGD3, revealing that the glycerol side chain of the sialic acids in both GD3s was an important structure of the epitope.

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The Committee on Safety of Medicine imposed the 1995 restriction after a study suggested a small increase in the risk of deep vein thrombosis. In the control rats pretreated with the vehicle, transient forebrain ischemia-induced delayed neuronal death in the hippocampal CA1 region was observed seven days after reperfusion. The mechanism of these SEB-induced pulmonary lesions was not determined.

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Information was collected on demographic, social, economic, behavioral, biological and care management variables. The predominance of a colonization-type history also highlights concerns about analyses based on single-locus data where genetic hitchhiking may be incorrectly inferred as colonization. Once-daily aminoglycoside dosing has many advantages and has been widely advocated. Capillary LC/MS provided a means for the separation and identification of these enzymatically derived peptides in a fraction of the time that would have been required by gas-phase Edman sequence analysis.

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Antidiarrheal activity, chemical and toxicity profile of Berberis aristata. The elopement of a child with Asperger syndrome was assessed using functional analyses and was treated in two school settings (classroom and resource room). The common pathogen of ocular fungal infection is Candida, which is different from the etiological characteristics in other areas possibly in association with the tropical climate. When prices go down and quality improves as a result of competitive market forces, then the market has functioned properly and has served its purpose.

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There was a trend that reduced expression of Mad1 was associated with poor survival of the patients. Intracellular injection of EGTA with the help of 10nA 5-10 min microiontophoresis through a multibarrel microelectrode evoked a weak increase in the amplitude of the ICa before AS-100 application and a complete abolition of the inhibitory effect of AS-100 on the ICa. Remarkably selective reduction of the alpha,beta-carbon-carbon double bond in highly activated alpha,beta,gamma,delta-unsaturated alkenes by the InCl3-NaBH4 reagent system.

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Identification of late differentiation antigens of human cornified epithelia, expressed in re-organized desmosomes and bound to cross-linked envelope. A small number of the cells began to show abnormal morphology, such as indistinct cell boundaries, fibroid appearance, or giant cell formation, as the passage increased, particularly after the 5th passage.

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The purpose of this study is to assess the intrasession repeatability of ocular aberration measurements in the peripheral visual field with a commercially available Shack-Hartmann aberrometer (complete ophthalmic analysis system-high definition-vision research). Pharmacological options are available but none have proven optimal efficacy. Partial vertebral height restoration achieved at percutaneous vertebroplasty did not result in additional pain relief or improved quality of life beyond cement fixation alone.

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In a 1-year follow-up study we examined changes in liver-derived enzymes and their association with self-reported alcohol consumption. We have observed that patients with 8q12 duplication share a common recognizable phenotype characterized by DRS, developmental delay and facial features. Calcium supplementation does not decrease rectal mucosal proliferation, as measured by PCNA (and BrdU) immunohistochemistry, in patients with previous large-bowel adenomas. To obtain information about the career paths of doctors who had completed general practice vocational training since 1990, and to compare the results with previously published data.

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Both Iso- and GRF-stimulated GH release were preceded by an increase in cAMP content in the pituitary cells. The aim of this study is to comprehensively characterize genome copy number aberrations in medulloblastomas using high-resolution array comparative genomic hybridization. Three preruminant calves were fitted with catheters in portal and hepatic veins and in a mesenteric artery.

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Conversely, lowering Hsps in cancer tissues can amplify the effectiveness of chemo- or radiotherapy. Six GH-deficient adults were given an isocaloric diet enriched in cholesterol and saturated fat for 17 days with and without GH therapy (1-1.5 U/day). Transmission/disequilibrium test based on haplotype sharing for tightly linked markers. In an initial attempt to understand the molecular mechanisms regulating the general anergy induced by the viral infection, we have analyzed the transcription of IL-2 and of p55 IL-2R alpha gene, two genes involved in T cell proliferation. New research initiatives in Canada for end-of-life and palliative care.

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